What are Opioids?

Opioids are a class of drugs derived from the opium poppy plant that are used for pain relief and non-prescription use. Opioids include synthetic opioids like heroin and “painkillers” including oxycodone, codeine, morphine, and many others. Addiction risk is high with opioids including prescription use.

Prevalence

  • More than 131 million opioid prescriptions were dispensed to American patients in 2022—with wide variation across states. Anyone who takes prescription opioids can become addicted to them. In fact, as many as one in four patients receiving long-term opioid therapy in a primary care setting struggles with opioid addiction.

  • According to the National Institute on Drug Abuse, opioid-involved overdose deaths rose from 21,089 in 2010 to 47,600 in 2017 and remained steady through 2019. There was a significant increase in 2020 with 68,630 reported deaths and again in 2021 with 80,411 reported overdose deaths.

  • Over 75% of the nearly 107,000 drug overdose deaths in 2021 involved an opioid.

Effects

In addition to the serious risks of addiction, abuse, and overdose, the use of prescription opioids can have a number of side effects, even when taken as directed:

  • Tolerance—meaning you might need to take more of the medication for the same pain relief
  • Physical dependence—meaning you have symptoms of withdrawal when the medication is stopped
  • Increased sensitivity to pain
  • Constipation
  • Nausea, vomiting, and dry mouth
  • Sleepiness and dizziness
  • Confusion
  • Depression
  • Low levels of testosterone that can result in lower sex drive, energy, and strength
  • Itching and sweating

Myths and Opioids

People have been dying of drug overdoses for too long, but this is different. What makes the opioid crisis an epidemic is the widespread use2 and growing rate of death3 from these prescription medications. An estimated 4.5 million people have developed an addiction to opioids. Forty percent of all opioid overdose deaths4 involve prescription drugs. The impacts on people with opioid use disorder, their friends, families, communities and employers are significant. The misuse of opioids is costing businesses an estimated $25.5 billion per year.5 It costs the justice system $7.7 billion per year.

Under certain circumstances, opioids are the right choice. But they are among the most-used addictive drugs.7 Others in that category include benzodiazepines, sleep aids and barbiturates. Some opioids are so potent that people can become addicted within a few days of taking them as prescribed.

Opioid use disorder is a problem in big cities. But it’s also a big problem in medium cities, small cities, towns, villages, suburbs and rural areas.

 

In 2016, states that are considered more rural had the highest rates of drug overdose deaths.8 According to the Centers for Disease Control (CDC), the highest rates of overdose deaths (per 100,000 people) were:

 

West Virginia, 52

Ohio, 39.1

New Hampshire, 39

Pennsylvania, 37.9

Kentucky, 33.5

In addition, these states — more than half the country — experienced statistically significant increases in deaths from overdoses from 2015 to 2016: Connecticut, Delaware, Florida, Illinois, Indiana, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, New Jersey, New York, North Carolina, Ohio, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Vermont, Virginia, West Virginia and Wisconsin.

Opioids are killing people from every region of the country. Deaths occur in every age group, every income level and every ethnicity.

 

In 2016, 67 percent of those who died from an opioid overdose in the U.S. were male, and 33 percent were female. Eighty percent of those who died were white. Ten percent were black, and eight percent were Hispanic.9

 

West Virginia is the state with the highest death rate from opioids. Of those who died in 2016 of overdose, the age breakdown, which is similar to other states’ experience, was:10

 

Six percent were under 24 years old.

25 percent were 25-34.

30 percent were 35-44.

24 percent were 45-54.

15 percent were 55 and over.

Use of heroin is increasing at a faster rate for those who make $20,000 to $49,999 than those who make under $20,000. People often progress to heroin after prescription opioids.11,12

Opioid use disorder is a chronic condition. Willpower cannot cure it, just as willpower cannot cure diabetes or asthma.

One of the biggest challenges for those living with opioid use disorder is that their bodies have become dependent on opioids to function and feel “normal.” They have reached a point where not having the opioid will cause great physical pain.

As the disorder grows stronger, it can change the brain’s ability to reason and think. That makes it even harder for people to overcome opioid use disorder.

Are you worried about yourself or a friend?

If you are concerned about your own use of opioids, don’t wait! Talk with the health care professionals who prescribed the medications for you. If you are concerned about family members or friends, urge them to talk to whoever prescribed their medications. Effective treatment of an opioid use disorder can reduce the risk of overdose and help a person who is misusing or addicted to opioid medications attain a healthier life.


Once addicted, it can be hard to stop. In 2016, more than 11.5 million Americans reported misusing prescription opioids in the past year

Opioid tolerance occurs when a person using opioids begins to experience a reduced response to medication, requiring more opioids to experience the same effect.

Opioid dependence occurs when the body adjusts its normal functioning around regular opioid use. Unpleasant physical symptoms occur when medication is stopped.

Opioid addiction (Opioid use disorder (OUD)) occurs when attempts to cut down or control use are unsuccessful or when use results in social problems and a failure to fulfill obligations at work, school, and home. Opioid addiction often comes after the person has developed opioid tolerance and dependence, making it physically challenging to stop using opioids and increasing the risk of withdrawal.

Signs of OVERDOSE

Overdose is a life-threatening emergency, including the following:

  • The face is extremely pale and/or clammy to the touch.
  • The body is limp.
  • Fingernails or lips have a blue or purple cast.
  • The person is vomiting or making gurgling noises.
  • The person cannot be awakened from sleep or cannot speak.
  • Breathing is very slow or stopped.
  • The heartbeat is very slow or stopped.

 

Signs of OVERMEDICATION

This may progress to overdose, and include:

  • Unusual sleepiness or drowsiness.
  • Mental confusion, slurred speech, or intoxicated behavior.
  • Slow or shallow breathing.
  • Extremely small “pinpoint” pupils.
  • Slow heartbeat or low blood pressure.
  • Difficulty being awakened from sleep.

What are opioids?

What are opioids?

Opioid Overdose and Recovery

Opioid Overdose and Recovery



Page last modified February 27, 2024