Psychology

Behavioral Neuroscience

PSY 430 - Theories of Personality

PSY 330 - Foundations of Behavioral Neuroscience

PSY 300 - Research Methods

PSY 435 - Advanced Neuroscience and Behavior

My interest in neuroscience is carried by a passion for understanding the biological underpinnings of stress-sensitive psychiatric disorders with the goal of developing tools to better diagnose or treat these complex neurological disorders.  As PI of an undergraduate research laboratory, I prioritize individualized mentorship and robust experimental design as well as fostering relationships with other researchers within and beyond our institution.  I currently have two streams of research.  In collaboration with Dr. Hagenauer at U of M and the Brain Data Alchemy project, my students and I conduct meta-analyses of publicly available data exploring the impact of chronic stress on gene-expression across various tissues.  In collaboration with Dr. Risbrough at UCSD, my students and I are analyzing de-identified immune system markers from humans seeking treatment for PTSD at the VA to better understand the relationship between mood and inflammation.

Eudave, D. M., BeLow, M. N., Flandreau, E. I. (2018). Effects of high fat or high sucrose diet on behavioral-response to social defeat stress in mice. Neurobiology of Stress, 9, 1-8.

Flandreau, E. I., & Toth, M. (2018). Animal Models of PTSD: A Critical Review. Current topics in behavioral neurosciences, 38, 47-68.

Toth, M., Flandreau, E. I., Deslauriers, J., Geyer, M. A., Mansuy, I. M., Merlo Pich, E., & Risbrough, V. B. (2016). Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(6), 1681–1690.

Flandreau, E., Risbrough, V., Lu, A., Ableitner, M., Geyer, M. A., Holsboer, F., & Deussing, J. M. (2015). Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology, 53, 16–28.

Toth, M., Gresack, J. E., Bangasser, D. A., Plona, Z., Valentino, R. J., Flandreau, E. I., Mansuy, I. M., Merlo-Pich, E., Geyer, M. A., & Risbrough, V. B. (2014). Forebrain-specific CRF overproduction during development is sufficient to induce enduring anxiety and startle abnormalities in adult mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(6), 1409–1419.

Flandreau, E. I., Bourke, C. H., Ressler, K. J., Vale, W. W., Nemeroff, C. B., & Owens, M. J. (2013). Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala. Psychoneuroendocrinology, 38(8), 1349–1361.

Sink, K. S., Walker, D. L., Freeman, S. M., Flandreau, E. I., Ressler, K. J., & Davis, M. (2013). Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety. Molecular psychiatry, 18(3), 308–319.

Gafford, G. M., Guo, J. D., Flandreau, E. I., Hazra, R., Rainnie, D. G., & Ressler, K. J. (2012). Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction. Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16330–16335.

Flandreau, E. I., Ressler, K. J., Owens, M. J., & Nemeroff, C. B. (2012). Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus. Psychoneuroendocrinology, 37(1), 27–38.