Chris Pearl
Associate Professor & Department Chair
Email
[email protected]
Office
215 Henry Hall
Phone
(616) 331-3221
COURSES TAUGHT
BMS 251- Anatomy and Physiology II Lab
BMS 290 - Human Physiology
BMS 391 - Human Physiology Lab
BMS 409/509 - Endocrinology
BMS 495 - Concepts in Wellness
BMS 695 - Master's Thesis Research
HNR 499 - Honors Senior Project
EDUCATION
Postdoctoral Scholar, Washington University in St. Louis School of Medicine, Reproductive Endocrinology
Ph.D., University of California Davis, Physiology
M.S., University of the Pacific, Biological Sciences
B.S., Saint Mary’s College of California, Biology
RESEARCH INTERESTS
The overall focus of my research is to investigate the role of hormone signaling in the male reproductive tract with the goal of better understanding male fertility and infertility. Control of spermatogenesis and sperm production is hormonally regulated through the hypothalamic-pituitary-gonadal axis. Classically, testosterone and other androgens have been associated with the male, while estradiol and other estrogens have been associated with the female. However, the testes produce significant amounts of estradiol in addition to testosterone and males unable to produce estrogens are infertile. Results from my research, and other groups, reveal that estrogen receptors are expressed within the testis and epididymis of multiple species. This indicates that the male reproductive tract in mammals is both a source and target for estrogen regulation. The mechanisms by which estrogen regulates sperm production and maturation remain largely unknown, but this knowledge is essential for further progress in understanding male fertility. Elucidating these mechanisms is the long-term objective of my research program. Projects in my lab investigate the effects of estrogen signaling throughout the lifespan (i.e. development, adulthood, aging) using rodent models.