BMS Seminar: Seed and Soil: Compartment-Resolved Profiling of Epithelial Ovarian Cancers
Friday, April 3, 2026
12:00 p.m. - 1:00 p.m.
Allendale Campus
Faculty
Epithelial ovarian cancers (EOCs) comprise biologically distinct
histotypes that arise
within shared anatomical niches where
tumor–stroma interactions shape tumor behavior
and therapeutic
response. However, whether different histotypes engage common
stromal programs, and how stromal signals influence canonical
molecular subtypes
remains unclear, as most classification
frameworks rely on bulk profiling that conflates
epithelial and
stromal contributions. Here, we performed compartment-resolved
transcriptomic and epigenomic profiling of matched carcinoma and
stroma across clear
cell (CCOC), endometrioid (ENOC), and
high-grade serous ovarian cancers (HGSC).
Carcinoma profiles
segregated strongly by histotype, whereas stromal profiles showed
minimal histotype specificity and instead resolved into four shared
groups (S1–S4). The
S4 subtype, marked by a desmoplastic,
myofibroblast-rich program, was enriched in
omental tumors and
corresponded to the HGSC C1/Mesenchymal signature. We show
this
subtype largely reflects tumor-extrinsic programs and is present
beyond HGSC.
Compartment-resolved analyses also refine the
interpretation of other molecular
carcinoma subtypes and reveal
distinct carcinoma-intrinsic EMT-like programs.
Location Information
Manitou (MAN) 107
Download parking map for the Allendale Campus
Contact Information
Catherine Miller
616-901-5868
Hosting Department, Organization, or Business
Biomedical Sciences Department
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This event was added to the calendar by Catherine Miller (millec1@gvsu.edu) on Thursday, March 26, 2026 and was last updated on Friday, March 27, 2026 at 2:43 p.m.