BMS Seminar-Real-time Nitric Oxide (NO) Detection for Understanding Complex Physiological Roles of NO

Friday, April 5, 2024
12:00 p.m.
Allendale Campus
Alumni, Community, Faculty, Staff, Students

Dr. Megan C. Frost, PhD (Founder and CTO of Sterile State, LLC)

Nitric oxide (NO) is one of the most important small signaling molecule in biological systems. It regulates various biological responses in both physiological and pathological conditions, often times producing seemingly contradictory results depending on the state of NO production. The details of the effects of NO are highly dependent on the level of NO that cells experiences and the temporal aspect of when and how long cells are exposed to NO. We have developed a tool that will allow real-time measurement of NO produced by cells in environments that do not deviate from established cell culture conditions and techniques. A specific example of using this CellNO trap is in studying the cells predominantly involved in diabetic foot ulcers (DFU). Diabetic foot ulcers are a major health problem associated with diabetes mellitus. Impaired nitric oxide (NO) production has been shown to be a major contributor to the dysregulation of healing in DFU. The level of impairment is not known primarily due to challenges with measuring NO. Understanding the actual NO dysregulation in macrophages, fibroblast, and keratinocyte as they participate in wound healing will allow the development of better treatment options.

Location Information

Mackinac Hall BLL110

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Contact Information

Professor John Capodilupo, Chair BMS Seminar Series ([email protected])

Hosting Department, Organization, or Business

Department of Biomedical Sciences

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This event was added to the calendar by Maria Kwesiga ( on Thursday, March 28, 2024 and was last updated on Monday, April 1, 2024 at 8:21 a.m.