BMS Seminar-Myocardial Ischemia; Effects of Treatment with Stem Cells

Friday, September 29, 2023
12:00 p.m. - 1:00 p.m.
Allendale Campus
Alumni, Community, Faculty, Staff, Students

Jack Tietema

Bone marrow-derived mesenchymal stem cells (BM-MSC) are reported to induce beneficial effects in the heart following ischemia, but a loss of these cells within hours of implantation could significantly diminish their long-term effect. We hypothesized that early coupling between BM-MSC and ischemic cardiomyocytes through gap junctions (GJ) may play an important role in stem cell survival and retention in the acute phase of myocardial ischemia. While functional GJ are critical for the long-term integration of stem cells within the myocardium, early GJ communication may represent a novel paradigm whereby ischemic cardiomyocytes induce a “bystander effect” when coupled to newly transplanted BM-MSC and thus impair cell retention and survival.

Location Information

Mackinac Hall BLL 110

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Contact Information

Professor John Capodilupo, Chair BMS Seminar Series ([email protected])

Hosting Department, Organization, or Business

Department of Biomedical Sciences


biomedical presentation research

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This event was added to the calendar by Maria Kwesiga ( on Sunday, September 24, 2023 and was last updated on Wednesday, September 27, 2023 at 10:59 a.m.