Alex MacDonald

Synthesis of Rigid Analogs of Thyronamine

The contemporary model of metabolism is centered upon the homeostatic regulation of thyroxine, and triiodothyronine.   Once these potent hormones enter the bloodstream, it causes a body wide upregulation of sodium channels, increased heart rate and increased internal temperatures.  Bluntly, these hormones drive growth and metabolism.

Recently, however, the discovery of 3-Iodothyronamine (abbreviated T1AM) has begun to demand a modification of the accepted mechanism of metabolism.  This hormone, when delivered intravenously causes a complete inversion of physiological response to that of thyroxine and triiodothyronine.  T1AM causes a decrease in cardiac drive, decrease in internal body temperatures and an overall down-regulation of metabolism.  It is proposed that the mechanism of metabolism may not solely rely upon the regulation and inhibition of thyroxine and triiodothyronine, but rather the synergistic control of both the former hormones and the recently identified T1AM.

In the lab, our team is investigating methods to synthesis a more potent analog of T1AM.  The effectiveness of the compound is evaluated based upon it’s activation of trace amine-associated receptor (abbreviated TAAR). By changing the molecular structure, the hormone’s reactivity may be changed.  This research holds promise for those suffering with hyperthyroidism and hypothyroidism conditions, where perhaps thyroxine and triodothyronine levels may be better managed through the regulation of T1AM.

Faculty Mentor: Matthew Hart, Chemistry

Page last modified July 22, 2010