Beckman Scholars Program Faculty Mentor: Brad Wallar, Ph.D.
Dr. Wallar’s laboratory involves the structural and functional characterization of Acinetobacter-Derived Cephalosporinase-7 (ADC-7), a β-lactamase in Acinetobacter baumannii that plays a major role in the antibiotic resistance of this pathogenic bacterium. His current research focuses on developing structure/activity relationships for novel compounds that inhibit ADC-7. The ADC-7/inhibitor complexes offer useful information for the structure-based optimization of this class of novel β-lactamase inhibitors against a clinically relevant antibiotic resistance target. In the Wallar laboratory, undergraduate researchers take ownership of projects that involve a multidisciplinary approach, including site-directed mutagenesis, protein expression and purification, protein crystallization, X-ray crystallography, and enzyme kinetics.