Alexandra Gabrielli ACF Abstract FY12

"Synthesis and Florescence Properties of C-6 Modified 2'-Deoxynucleosides"

Conference Name: 242nd National Meeting of the American Chemical Society

The synthesis of C-6 modified 2’-deoxyadenosine and 2’-deoxyguanosine is reported.  Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2’-deoxynucleosides by Pd-catalyzed cross-coupling methods.  The fluorescence properties of these novel alkynylated 2’-deoxyadenosine and 2’-deoxyguanosine analogs have been determined.  The results of our preliminary studies will be presented.

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