242nd National Meeting of the American Chemical Society
The synthesis of C-6 modified 2-deoxyadenosine and 2-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2-deoxyadenosine and 2-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.