Francisella tularensis is a significant biodefense concern because of its extreme pathogenicity and low infectivity. Our lab have developed various genetic systems, including a Tn5 transposition system, which has allowed the creation of bacterial mutants so that various virulence properties of this organism can be deleted and studied. Current work is focused on identifying and characterizing Francisella tularensis mutants with alterations in a variety of virulence strategies in this organism including growth and survival in human macrophages, inactivation of human neutrophil responses, entry and growth in primary human small airway epithelial cells and regulation of known and unknown virulence factors.
This event is sponsored by the GVSU Microbiology Club and is part of the BMS Seminar Series. Dr. Jones's seminar will be from 12-1 PM followed by a meet and greet pizza luncheon.
M. Aaron Baxter: firstname.lastname@example.org