Project Title: Development of computer-aided detection (CAD) tool for liver metastasis micro CT imaging using targeted contrast agent
Preclinical in-vivo micro CT studies of liver metastasis are difficult due to poor inherent soft tissue contrast and the need for highly technical, manual analysis of the data. Research has implicated that Kupffer cells in the liver encapsulate liver metastases providing an opportunity to deliver macrophage-specific contrast agents for the detection of small metastatic lesions. The Kupffer cell targeting contrast agent will enable automated detection of liver lesions via CAD software and allow for large scale studies. This imaging method could be a useful tool to facilitate longitudinal imaging of liver metastases in mice and has the potential for translation into clinical practice.
Page last modified February 22, 2012