Sok Kean Khoo Ph.D.

Khoo

Distinguished Associate Professor of Molecular Genomics Department of Cell and Molecular Biology

554 Cook-DeVos Center for Health Sciences

Phone: 616-331-5916 Email: khoos@gvsu.edu

Office Hour

3353 KHS: MW 10-11 am (CMB 405)

716 EC: T 5:30-6 pm (CMB 697) or by appointment 

Education

Postdoctoral Fellow (Cancer Genetics and Genomics) Van Andel Institute, Grand Rapids, MI

Ph.D. (Fisheries Genetics) Tokyo University of Marine Science and Technology, Tokyo, Japan

M.S. (Reproductive Physiology) University of Science Malaysia, Penang, Malaysia

B.S. (Aquatic Biology, minor in Management) University of Science Malaysia, Penang, Malaysia

Courses

CMB 405 - Cellular & Molecular Biology

CMB 480 / 580 - Responsible Conduct of Research

CMB 697 - Colloquium in Biotechnology

Research Interests

Molecular biomarker discovery / development, biospecimen science, host response to environmental / climate changes

Current Grant Support Research

Global genomic and proteomic profiling of African children with typhoid fever (NIH NIAID subaward; PI Obaro of University Nebraska Medical Center)

Current Laboratory Members

Sapana Shinde (Special Project Graduate Assistant / MS Thesis Research)

Sarah Brown (BS Independent Research)

Brooke Armistead (BS Independent Research)

Emma Hahs (BS Independent Research)

Aaron Ripley (Student Worker)

Patent

MicroRNA biomarkers for diagnosing Parkinson's disease #US/349808

Publications (selected from 60)

Neuroscience

Khoo, S.K. Biofluid-based biomarkers for Parkinson's disease: a new paradigm (Editorial).  AIMS Medical Science, 2:371-373 (2015)

Petillo, D., S. Orey, A.C. Tan, L. Forsgren, and S.K. Khoo. Parkinson's disease-related circulating microRNA biomarkers - a validation study. AIMS Medical Science, 2:7-14 (2015)(http://www.aimspress.com/aimsmeds/ch/reader/view_abstract.aspx?file_no=Med2014014&flag=1)

Shinde, S., S. Mukhopadhyay, G. Mohsen, and S.K. Khoo. Biofluid-based microRNA biomarkers for Parkinson's disease: an overview and update. AIMS Medical Science, 2:15-25 (2015)(http://www.aimspress.com/aimsmeds/ch/reader/view_abstract.aspx?file_no=Med2014015&flag=1)

Khoo, S.K., L.A. Neuman, L. Forsgren, D. Petillo, and P. Brundin. Could microRNA expression changes be a reliable clinical biomarker for Parkinson's disease? Neurodegenerative Disease Management, 3:455-465 (2013)

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatrics Research, 73:450-456 (2013)(http://www.nature.com/pr/journal/v73/n4-1/abs/pr2012200a.html)

Khoo, S.K., D. Petillo, U.J. Kang, J.H. Resau, B. Berryhill, J. Linder, L. Forsgren, L.A. Neuman, and A.C. Tan. Plasma-based circulating microRNA biomarkers for Parkinson's disease. Journal of Parkinson's Disease, 2:321-331(2012)(http://iospress.metapress.com/content/584k478ngh1m1u04/?p=c9d4cb5c4f634fef82b607328a53e102&pi=7)

Cancer

Dalgliesh, G.L., K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, J. Teague, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, S. Forbes, M. Jia, D. Jones, H. Knott, C.Y. Kok, K.W. Lau, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, S. O'Meara, E. Pleasance, A. Rajasingham, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, K. Turrell, K.J. Dykema, S.K. Khoo, D. Petillo, B. Wondergem, J. Adema, R.J. Kahnoski, B.T. Teh, M.R. Stratton, and P.A. Futreal. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature, 463:360-363 (2010)

Khoo, S.K., P. Pendek, R. Nickolov, D.C. Luccio-Camelo, T.L. Newton, A. Massie, D. Petillo, J. Menon, D. Cameron, B.T. Teh, and S-P. Chan. Genome-wide scan identified novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. Endocrine-Related Cancer, 16: 1957-1063 (2009)

van Haaften, G., G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O'Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M-L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y-T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics, 41:521-523 (2009)

Matsuda, D., S.K. Khoo, A. Massie, M. Iwamura, J. Chen, D. Petillo, B. Wondergem, M. Avallone, S.J. Kloostra, M-H. Tan, J. Koeman, Z. Zhang, R.J. Kahnoski, The French Kidney Cancer Study Group, S. Baba, and B.T. Teh. Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters, 272: 260-267 (2008)

Greenman, C., P. Stephens, R. Smith, G. Dalgliesh, C. Hunter, G. Bignell, H. Davies, J. Teague, A. Butler, C. Stevens, S. Edkins, S. O'Meara, T. Avis, S. Barthorpe, G. Bhamra, G. Buck, B. Choudhury, J. Clements, J. Cole, E. Dicks, S. Forbes, K. Gray, K. Halliday, R. Harrison, K. Hills, J. Hinton, A. Jenkinson, D. Jones, A. Menzies, T. Mironenko, J. Perry, K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts, J. Varian, T. Webb, S. West, S. Widaa, A. Yates, D.P. Cahill, D.N. Louis, P. Goldstraw, A.G. Nicholson, F. Brasseur, L. Looijenga, B.L. Weber, Y-E. Chiew, A. deFazio, M.F. Greaves, A.R. Green, D.F. Easton, G. Chenevix-Trench, S.K. Khoo, M-H. Tan, B.T. Teh, S.T. Yuen, S.Y. Leung, R. Wooster, P.A. Futreal, and M. Stratton. Patterns of somatic mutation in human cancer genomes. Nature, 446:153-158 (2007)

Sweet, K, J. Willis, X.-P. Zhou, C. Gallione, T. Sawada, P. Alhopuro, S.K. Khoo, A. Patocs, C. Martin, S. Bridgeman, J. Heinz, R. Pilarski, R. Lehtonen, T. Prior, T. Frebourg, B.T. Teh, D.A. Marchuk, L.A. Aaltonen, and C. Eng. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. Journal of American Medical Association, 294:2465-2473 (2005)

Chen, J., W-O. Lui, M.D. Vos, G.J. Clark, M. Takahashi, J. Schoumans, S.K. Khoo, D. Petillo, T. Lavery, J. Sugimura, D. Astuti, C. Zhang, S. Kagawa, E. Maher, C. Larsson, A.S. Alberts, H. Kanayama, and B.T. Teh. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell, 4:405-413 (2003)

Khoo, S.K., K. Kahnoski, J. Sugimura, D. Petillo, J. Chen, K. Shockley, J. Ludlow, R. Knapp, S. Giraud, S. Richard, M. Nordenskjöld, and B.T. Teh. Inactivation of BHD in sporadic renal tumors. Cancer Research, 63:4583-4587 (2003)

Khoo, S.K., S. Giraud, K. Kahnoski, J. Chen, O. Motorna, R. Nickolov, O. Binet, D. Lambert, J. Friedel, R. Levy, S. Frelicot, P. Wolkenstein, P. Hammel, U. Bergerheim, M.-A, Hedblad, M. Bradley, B.T. Teh, M. Nordenskjöld, and S. Richard. Clinical and genetic studies of Birt-Hogg-Dubé syndrome. Journal of Medical Genetics, 39:906-912 (2002)

Khoo, S.K., M. Bradley, F.K. Wong, M.-A. Hedblad, M. Nordenskjöld, and B.T. Teh. Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2. Oncogene, 20:5239-5242 (2001)

Fisheries Science

Ozaki, A., S.K. Khoo, Y. Yoshiura, M. Ototake, T. Sakamoto, J.M. Dijkstra, and N. Okamoto. Identification of additional quantitative trait loci (QTL) responsible for susceptibility to infectious pancreatic necrosis virus in rainbow trout. Fish Pathology, 42:131-140 (2007)

Khoo, S.K., A. Ozaki, F. Nakamura, T. Akutsu, S. Ishimoto, R. Nickolov, T. Sakamoto, A. Tetsuya, M. Mochizuki, I. Denda, and N. Okamoto. Identification of a novel chromosomal region associated with infectious hematopoietic necrosis (IHN) resistance in rainbow trout Oncorhynchus mykiss. Fish Pathology, 39:95-101 (2004)

Ozaki, A., T. Sakamoto, S.K. Khoo, K. Nakamura, M.R.M. Coimbra, T. Akutsu, and N. Okamoto. Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout ( Oncorhynchus mykiss). Molecular Genetics and Genomics, 265:23-31 (2001)

Sakamoto, T., R.G. Danzmann, K. Gharbi, P. Howard, A. Ozaki, S.K. Khoo, R.A. Woram, N. Okamoto, M.M. Ferguson, L.-E. Holm, R. Guyomard, and B. Hoyheim. A microsatellite linkage map of rainbow trout ( Oncorhynchus mykiss) characterized by large sex-specific differences in recombination rates. Genetics, 155:1331-1345 (2000)

Khoo, S.K., A. Ozaki, T. Sakamoto, and N. Okamoto. Four highly polymorphic dinucleotide microsatellites in rainbow trout ( Oncorhynchus mykiss). Animal Genetics, 31:73 (2000)

Others

Joshi, N., R-W. Su, C. Gadisetti, S.K. Khoo, J-W. Jeong, S. Young, B. Lessy, and A. Fazleabas. Altered expression of microRNA-451 (miR-451) in eutopic endometrium of baboons (Papio anubis) with endometriosis. Human Reproduction (in press)

Grauholm, J. S.K. Khoo, R.Z. Nickolov, J.B. Poulsen, M. Baekvard-Hansen, C.S. Hansen, D.M. Hougaard, and M.V. Hollegaard. Gene expression profiling of archived dried blood spot samples from the Danish neonatal screening biobank.  Molecular Genetics and Metabolism, 116: 119-124 (2015) 

Khoo, S.K., K. Dykema, N.M. Vadlapatla, D. LaHaie, S. Valle, D. Satterthwaite, S.A. Ramirez, J.A. Carruthers, P.T. Haak, and J.H. Resau. Acquiring genome-wide gene expression profiles in Guthrie card blood spots using microarrays. Pathology International, 61:1-6 (2011)

Khoo, S.K., D. Petillo, M. Parida, A.C. Tan, J.H. Resau, and S.K. Obaro. Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. BMC Infectious Disease, 11:241(2011)