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Sok Kean Khoo Ph.D.


Distinguished Associate Professor of Molecular Genomics Department of Cell and Molecular Biology

Co-Director, Grand Valley State University Beckman Scholars Program

554 Cook-DeVos Center for Health Sciences

Phone: 616-331-5916 Email:

Office Hours

3353 KHS: MW 1-2 pm (CMB 405)

716 EC: Tue 5:15-6 pm (CMB 697)

554 CHS: Tue 8:30-9am (CMB 480/580)

or by appointment 


Postdoctoral Fellow (Cancer Genetics and Genomics) Van Andel Institute, Grand Rapids, MI

Ph.D. (Fisheries Genetics) Tokyo University of Marine Science and Technology, Tokyo, Japan

M.S. (Reproductive Physiology) University of Science Malaysia, Penang, Malaysia

B.S. (Major: Aquatic Biology, Minor: Management) University of Science Malaysia, Penang, Malaysia


CMB 405 - Cellular & Molecular Biology

CMB 480 / 580 - Responsible Conduct of Research

CMB 501 - Scientific Communication

CMB 610 - Foundations in Biotechnology

CMB 697 - Colloquium in Biotechnology (Capstone)

Research Interests

Molecular biomarker discovery / development / validation, biospecimen science, host response to environmental or climate change

Current Grant Support 

Grand Valley State University Beckman Scholars Program (Beckman Foundation; PIs: Khoo and Mendoza)

Global genomic and proteomic profiling of African children with typhoid fever (NIH NIAID subaward; PI Obaro of University Nebraska Medical Center)

Completed Grant Support (past 5 years)

The Michael J Fox Foundation for Parkinson's Research, The Michigan Bloodspot Environmental Epidemiology Project, Spectrum Health Digestive Disease Institute

Laboratory Members (Winter 2017)

Rebecca "Beckey" Mitchell (Special Project Graduate Assistant)

Brooke Armistead (MS Thesis Research)

Kevin Mittner (MS Thesis Research)

Sarah Thompson (MS Thesis Research)

Emma Hahs (BS Honor Thesis Research)

Trevor Guida (BS Independent Research)

Manuscript Invitation

You are invited to submit a research or review article to Metabolites' Special Issue "Biomarkers for Neurodegenerative Diseases"  

Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal that has been indexed by PubMed, Scopus and Web of Science.

Please contact Special Issue Editor for any questions.

Publications (selected from 63)

Full publication list:


Khoo, S.K. Biofluid-based biomarkers for Parkinson's disease: a new paradigm (Editorial). AIMS Medical Science, 2:371-373 (2015)

Petillo, D., S. Orey, A.C. Tan, L. Forsgren, and S.K. Khoo. Parkinson's disease-related circulating microRNA biomarkers - a validation study. AIMS Medical Science, 2:7-14 (2015)

Shinde, S., S. Mukhopadhyay, G. Mohsen, and S.K. Khoo. Biofluid-based microRNA biomarkers for Parkinson's disease: an overview and update. AIMS Medical Science, 2:15-25 (2015)

Khoo, S.K., L.A. Neuman, L. Forsgren, D. Petillo, and P. Brundin. Could microRNA expression changes be a reliable clinical biomarker for Parkinson's disease? Neurodegenerative Disease Management, 3:455-465 (2013)

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatrics Research, 73:450-456 (2013)

Khoo, S.K., D. Petillo, U.J. Kang, J.H. Resau, B. Berryhill, J. Linder, L. Forsgren, L.A. Neuman, and A.C. Tan. Plasma-based circulating microRNA biomarkers for Parkinson's disease. Journal of Parkinson's Disease, 2:321-331(2012)


Gao C, Y. Su, J. Koeman, E. Haak, K. Dykema, C. Essenberg, E. Hudson, D. Petillo, S.K. Khoo, and G.F. Vande Woude.  Chromosome instability drives phenotypic switching to metastasis.  Proceedings of National Academy of Science, 113:14793–14798 (2016)

Dalgliesh, G.L., K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, J. Teague, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, S. Forbes, M. Jia, D. Jones, H. Knott, C.Y. Kok, K.W. Lau, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, S. O'Meara, E. Pleasance, A. Rajasingham, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, K. Turrell, K.J. Dykema, S.K. Khoo, D. Petillo, B. Wondergem, J. Adema, R.J. Kahnoski, B.T. Teh, M.R. Stratton, and P.A. Futreal. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature, 463:360-363 (2010)

Khoo, S.K., P. Pendek, R. Nickolov, D.C. Luccio-Camelo, T.L. Newton, A. Massie, D. Petillo, J. Menon, D. Cameron, B.T. Teh, and S-P. Chan. Genome-wide scan identified novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. Endocrine-Related Cancer, 16: 1957-1063 (2009)

van Haaften, G., G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O'Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M-L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y-T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics, 41:521-523 (2009)

Matsuda, D., S.K. Khoo, A. Massie, M. Iwamura, J. Chen, D. Petillo, B. Wondergem, M. Avallone, S.J. Kloostra, M-H. Tan, J. Koeman, Z. Zhang, R.J. Kahnoski, The French Kidney Cancer Study Group, S. Baba, and B.T. Teh. Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters, 272: 260-267 (2008)

Greenman, C., P. Stephens, R. Smith, G. Dalgliesh, C. Hunter, G. Bignell, H. Davies, J. Teague, A. Butler, C. Stevens, S. Edkins, S. O'Meara, T. Avis, S. Barthorpe, G. Bhamra, G. Buck, B. Choudhury, J. Clements, J. Cole, E. Dicks, S. Forbes, K. Gray, K. Halliday, R. Harrison, K. Hills, J. Hinton, A. Jenkinson, D. Jones, A. Menzies, T. Mironenko, J. Perry, K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts, J. Varian, T. Webb, S. West, S. Widaa, A. Yates, D.P. Cahill, D.N. Louis, P. Goldstraw, A.G. Nicholson, F. Brasseur, L. Looijenga, B.L. Weber, Y-E. Chiew, A. deFazio, M.F. Greaves, A.R. Green, D.F. Easton, G. Chenevix-Trench, S.K. Khoo, M-H. Tan, B.T. Teh, S.T. Yuen, S.Y. Leung, R. Wooster, P.A. Futreal, and M. Stratton. Patterns of somatic mutation in human cancer genomes. Nature, 446:153-158 (2007)

Sweet, K, J. Willis, X.-P. Zhou, C. Gallione, T. Sawada, P. Alhopuro, S.K. Khoo, A. Patocs, C. Martin, S. Bridgeman, J. Heinz, R. Pilarski, R. Lehtonen, T. Prior, T. Frebourg, B.T. Teh, D.A. Marchuk, L.A. Aaltonen, and C. Eng. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. Journal of American Medical Association, 294:2465-2473 (2005)

Chen, J., W-O. Lui, M.D. Vos, G.J. Clark, M. Takahashi, J. Schoumans, S.K. Khoo, D. Petillo, T. Lavery, J. Sugimura, D. Astuti, C. Zhang, S. Kagawa, E. Maher, C. Larsson, A.S. Alberts, H. Kanayama, and B.T. Teh. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell, 4:405-413 (2003)

Khoo, S.K., K. Kahnoski, J. Sugimura, D. Petillo, J. Chen, K. Shockley, J. Ludlow, R. Knapp, S. Giraud, S. Richard, M. Nordenskjöld, and B.T. Teh. Inactivation of BHD in sporadic renal tumors. Cancer Research, 63:4583-4587 (2003)

Khoo, S.K., S. Giraud, K. Kahnoski, J. Chen, O. Motorna, R. Nickolov, O. Binet, D. Lambert, J. Friedel, R. Levy, S. Frelicot, P. Wolkenstein, P. Hammel, U. Bergerheim, M.-A, Hedblad, M. Bradley, B.T. Teh, M. Nordenskjöld, and S. Richard. Clinical and genetic studies of Birt-Hogg-Dubé syndrome. Journal of Medical Genetics, 39:906-912 (2002)

Khoo, S.K., M. Bradley, F.K. Wong, M.-A. Hedblad, M. Nordenskjöld, and B.T. Teh. Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2. Oncogene, 20:5239-5242 (2001)

Dried Bloodspots

Bybjerg-Grauholm J, C.M. Hagen, S.K. Khoo, M.L. Johannesen, C.S. Hansen, M. Bækvad-Hansen, M. Christiansen, D.M. Hougaard, and M.V. Hollegaard.  RNA sequencing of archived neonatal dried blood spots.  Molecular Genetics and Metabolism Reports, 10:33-37 (2017)

Ho, N.T., J.V. Busik, J.H. Resau, N. Paneth, and S.K. Khoo.  Effect of storage time on gene expression data acquired from unfrozen archived newborn blood spots. Molecular Genetics and Metabolism, 119:207-213 (2016)

Grauholm, J. S.K. Khoo, R.Z. Nickolov, J.B. Poulsen, M. Baekvard-Hansen, C.S. Hansen, D.M. Hougaard, and M.V. Hollegaard. Gene expression profiling of archived dried blood spot samples from the Danish neonatal screening biobank.  Molecular Genetics and Metabolism, 116: 119-124 (2015) 

Wei, C., Q. Lu, S.K. Khoo, M. Lenski, R. Fichorova, and N. Paneth.  Comparison of frozen and unfrozen blood spots for gene expression studies.  Journal of Pediatrics, 164:189-191 (2014)

Slaughter, J., C. Wei, S. Korzeniewski, Q. Lu, J.S. Beck, S.K. Khoo, A. Brovont, J. Maurer, D. Martin, M. Lenski, and N. Paneth.  High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.  Journal of Maternal-Fetal & Neonatal Medicine, 26:1765-1767 (2013)

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatrics Research, 73:450-456 (2013)

Resau, J.H., N.T. Ho, K. Dykema, M.S. Faber, J. V. Busik, R.Z. Nickolov, K.A. Furge, N. Paneth, S. Jewell, and S.K. Khoo.  Evaluation of sex-specific gene expression in archived dried blood spots (DBS).  International Journal of Molecular Sciences, 13:9599-9608 (2012)

Khoo, S.K., K. Dykema, N.M. Vadlapatla, D. LaHaie, S. Valle, D. Satterthwaite, S.A. Ramirez, J.A. Carruthers, P.T. Haak, and J.H. Resau. Acquiring genome-wide gene expression profiles in Guthrie card blood spots using microarrays. Pathology International, 61:1-6 (2011)

Fisheries Science

Ozaki, A., S.K. Khoo, Y. Yoshiura, M. Ototake, T. Sakamoto, J.M. Dijkstra, and N. Okamoto. Identification of additional quantitative trait loci (QTL) responsible for susceptibility to infectious pancreatic necrosis virus in rainbow trout. Fish Pathology, 42:131-140 (2007)

Khoo, S.K., A. Ozaki, F. Nakamura, T. Akutsu, S. Ishimoto, R. Nickolov, T. Sakamoto, A. Tetsuya, M. Mochizuki, I. Denda, and N. Okamoto. Identification of a novel chromosomal region associated with infectious hematopoietic necrosis (IHN) resistance in rainbow trout Oncorhynchus mykiss. Fish Pathology, 39:95-101 (2004)

Ozaki, A., T. Sakamoto, S.K. Khoo, K. Nakamura, M.R.M. Coimbra, T. Akutsu, and N. Okamoto. Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout ( Oncorhynchus mykiss). Molecular Genetics and Genomics, 265:23-31 (2001)

Sakamoto, T., R.G. Danzmann, K. Gharbi, P. Howard, A. Ozaki, S.K. Khoo, R.A. Woram, N. Okamoto, M.M. Ferguson, L.-E. Holm, R. Guyomard, and B. Hoyheim. A microsatellite linkage map of rainbow trout ( Oncorhynchus mykiss) characterized by large sex-specific differences in recombination rates. Genetics, 155:1331-1345 (2000)

Khoo, S.K., A. Ozaki, T. Sakamoto, and N. Okamoto. Four highly polymorphic dinucleotide microsatellites in rainbow trout ( Oncorhynchus mykiss). Animal Genetics, 31:73 (2000)


Xu, E.H, Y. He, J. Shi, W. Yi, X. Ren, X. Gao, J. Li, N. Wu, K. Weaver, Q. Xie, S.K. Khoo, T. Yang, X. Huang, and K. Melcher.  Discovery of a highly potent glucocorticoid for asthma treatment.  Cell Discovery, 1:15035 (2015)

Joshi, N., R-W. Su, C. Gadisetti, S.K. Khoo, J-W. Jeong, S. Young, B. Lessy, and A. Fazleabas. Altered expression of microRNA-451 (miR-451) in eutopic endometrium of baboons (Papio anubis) with endometriosis. Human Reproduction, 30:2881-2891 (2015)

Khoo, S.K., D. Petillo, M. Parida, A.C. Tan, J.H. Resau, and S.K. Obaro. Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. BMC Infectious Disease, 11:241(2011)