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Sok Kean Khoo Ph.D.

Khoo

Distinguished Associate Professor of Molecular Genomics Department of Cell and Molecular Biology

554 Cook-DeVos Center for Health Sciences

Phone: 616-331-5916 Email: khoos@gvsu.edu

Office Hour

3353 KHS: MW 2-3 pm (CMB 405)

710 EC: Thu 5:30-6 pm (CMB 610) or by appointment 

Education

Postdoctoral Fellow (Cancer Genetics and Genomics) Van Andel Institute, Grand Rapids, MI

Ph.D. (Fisheries Genetics) Tokyo University of Marine Science and Technology, Tokyo, Japan

M.S. (Reproductive Physiology) University of Science Malaysia, Penang, Malaysia

B.S. (Aquatic Biology, minor in Management) University of Science Malaysia, Penang, Malaysia

Courses

CMB 405 - Cellular & Molecular Biology

CMB 480 / 580 - Responsible Conduct of Research

CMB 501 - Scientific Communication

CMB 610 - Foundations in Biotechnology

CMB 697 - Colloquium in Biotechnology

Research Interests

Molecular biomarker discovery / development / validation, biospecimen science, host response to environmental or climate change

Current Grant Support 

Global genomic and proteomic profiling of African children with typhoid fever (NIH NIAID subaward; PI Obaro of University Nebraska Medical Center)

Completed Grant Support (past 5 years)

The Michael J Fox Foundation for Parkinson's Research, The Michigan Bloodspot Environmental Epidemiology Project, Spectrum Health Digestive Disease Institute

Laboratory Members (Fall 2016)

Rebecca "Beckey" Mitchell (Special Project Graduate Assistant / MS Thesis Research)

Brooke Armistead (Combined MS/BS Independent Research, GVSU Student Summer Scholar Mary Beth Koeze Endowed Fellowship)

Emma Hahs (BS Independent Research, GVSU Student Summer Scholar)

Trevor Guida (BS Independent Research)

Publications (selected from 61)

Full publication list: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47741036/?sort=date&direction=descending

Neuroscience

Khoo, S.K. Biofluid-based biomarkers for Parkinson's disease: a new paradigm (Editorial). AIMS Medical Science, 2:371-373 (2015)  http://www.aimspress.com/medicalScience/2015/4/371

Petillo, D., S. Orey, A.C. Tan, L. Forsgren, and S.K. Khoo. Parkinson's disease-related circulating microRNA biomarkers - a validation study. AIMS Medical Science, 2:7-14 (2015)  http://www.aimspress.com/medicalScience/2015/1/7

Shinde, S., S. Mukhopadhyay, G. Mohsen, and S.K. Khoo. Biofluid-based microRNA biomarkers for Parkinson's disease: an overview and update. AIMS Medical Science, 2:15-25 (2015) http://www.aimspress.com/medicalScience/2015/1/15

Khoo, S.K., L.A. Neuman, L. Forsgren, D. Petillo, and P. Brundin. Could microRNA expression changes be a reliable clinical biomarker for Parkinson's disease? Neurodegenerative Disease Management, 3:455-465 (2013) http://www.futuremedicine.com/doi/full/10.2217/nmt.13.53

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatrics Research, 73:450-456 (2013) http://www.nature.com/pr/journal/v73/n4-1/full/pr2012200a.html

Khoo, S.K., D. Petillo, U.J. Kang, J.H. Resau, B. Berryhill, J. Linder, L. Forsgren, L.A. Neuman, and A.C. Tan. Plasma-based circulating microRNA biomarkers for Parkinson's disease. Journal of Parkinson's Disease, 2:321-331(2012) http://content.iospress.com/articles/journal-of-parkinsons-disease/jpd012144?resultNumber=0&totalResults=16&start=0&q=khoo&resultsPageSize=10&rows=10

Cancer

Dalgliesh, G.L., K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, J. Teague, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, S. Forbes, M. Jia, D. Jones, H. Knott, C.Y. Kok, K.W. Lau, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, S. O'Meara, E. Pleasance, A. Rajasingham, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, K. Turrell, K.J. Dykema, S.K. Khoo, D. Petillo, B. Wondergem, J. Adema, R.J. Kahnoski, B.T. Teh, M.R. Stratton, and P.A. Futreal. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature, 463:360-363 (2010) http://www.nature.com/nature/journal/v463/n7279/full/nature08672.html

Khoo, S.K., P. Pendek, R. Nickolov, D.C. Luccio-Camelo, T.L. Newton, A. Massie, D. Petillo, J. Menon, D. Cameron, B.T. Teh, and S-P. Chan. Genome-wide scan identified novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. Endocrine-Related Cancer, 16: 1957-1063 (2009) http://erc.endocrinology-journals.org/content/16/3/1057.full

van Haaften, G., G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O'Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M-L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y-T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics, 41:521-523 (2009) http://www.nature.com/ng/journal/v41/n5/full/ng.349.html

Matsuda, D., S.K. Khoo, A. Massie, M. Iwamura, J. Chen, D. Petillo, B. Wondergem, M. Avallone, S.J. Kloostra, M-H. Tan, J. Koeman, Z. Zhang, R.J. Kahnoski, The French Kidney Cancer Study Group, S. Baba, and B.T. Teh. Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters, 272: 260-267 (2008) http://www.cancerletters.info/article/S0304-3835(08)00498-9/abstract

Greenman, C., P. Stephens, R. Smith, G. Dalgliesh, C. Hunter, G. Bignell, H. Davies, J. Teague, A. Butler, C. Stevens, S. Edkins, S. O'Meara, T. Avis, S. Barthorpe, G. Bhamra, G. Buck, B. Choudhury, J. Clements, J. Cole, E. Dicks, S. Forbes, K. Gray, K. Halliday, R. Harrison, K. Hills, J. Hinton, A. Jenkinson, D. Jones, A. Menzies, T. Mironenko, J. Perry, K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts, J. Varian, T. Webb, S. West, S. Widaa, A. Yates, D.P. Cahill, D.N. Louis, P. Goldstraw, A.G. Nicholson, F. Brasseur, L. Looijenga, B.L. Weber, Y-E. Chiew, A. deFazio, M.F. Greaves, A.R. Green, D.F. Easton, G. Chenevix-Trench, S.K. Khoo, M-H. Tan, B.T. Teh, S.T. Yuen, S.Y. Leung, R. Wooster, P.A. Futreal, and M. Stratton. Patterns of somatic mutation in human cancer genomes. Nature, 446:153-158 (2007) http://www.nature.com/nature/journal/v446/n7132/full/nature05610.html

Sweet, K, J. Willis, X.-P. Zhou, C. Gallione, T. Sawada, P. Alhopuro, S.K. Khoo, A. Patocs, C. Martin, S. Bridgeman, J. Heinz, R. Pilarski, R. Lehtonen, T. Prior, T. Frebourg, B.T. Teh, D.A. Marchuk, L.A. Aaltonen, and C. Eng. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. Journal of American Medical Association, 294:2465-2473 (2005) http://jama.jamanetwork.com/article.aspx?articleid=201880

Gao, C.-F., Q. Xie, Y.-L. Su, J. Koeman, S.K. Khoo, M. Gustafson, B.S. Knudsen, R. Hay, N. Shinomiya, and G.F. Vande Woude.  Proliferation and invasion: plasticity in tumor cells.  Proceedings of National Academy of Science, 102:10528–10533 (2005)  http://www.pnas.org/content/102/30/10528.long

Chen, J., W-O. Lui, M.D. Vos, G.J. Clark, M. Takahashi, J. Schoumans, S.K. Khoo, D. Petillo, T. Lavery, J. Sugimura, D. Astuti, C. Zhang, S. Kagawa, E. Maher, C. Larsson, A.S. Alberts, H. Kanayama, and B.T. Teh. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell, 4:405-413 (2003)  http://www.cell.com/cancer-cell/abstract/S1535-6108(03)00269-1

Khoo, S.K., K. Kahnoski, J. Sugimura, D. Petillo, J. Chen, K. Shockley, J. Ludlow, R. Knapp, S. Giraud, S. Richard, M. Nordenskjöld, and B.T. Teh. Inactivation of BHD in sporadic renal tumors. Cancer Research, 63:4583-4587 (2003)  http://cancerres.aacrjournals.org/content/63/15/4583.long

Khoo, S.K., S. Giraud, K. Kahnoski, J. Chen, O. Motorna, R. Nickolov, O. Binet, D. Lambert, J. Friedel, R. Levy, S. Frelicot, P. Wolkenstein, P. Hammel, U. Bergerheim, M.-A, Hedblad, M. Bradley, B.T. Teh, M. Nordenskjöld, and S. Richard. Clinical and genetic studies of Birt-Hogg-Dubé syndrome. Journal of Medical Genetics, 39:906-912 (2002)  http://jmg.bmj.com/content/39/12/906.full

Khoo, S.K., M. Bradley, F.K. Wong, M.-A. Hedblad, M. Nordenskjöld, and B.T. Teh. Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2. Oncogene, 20:5239-5242 (2001)  http://www.nature.com/onc/journal/v20/n37/full/1204703a.html

Dried Bloodspots

Ho, N.T., J.V. Busik, J.H. Resau, N. Paneth, and S.K. Khoo.  Effect of storage time on gene expression data acquired from unfrozen archived newborn blood spots. Molecular Genetics and Metabolism (in press)

Grauholm, J. S.K. Khoo, R.Z. Nickolov, J.B. Poulsen, M. Baekvard-Hansen, C.S. Hansen, D.M. Hougaard, and M.V. Hollegaard. Gene expression profiling of archived dried blood spot samples from the Danish neonatal screening biobank.  Molecular Genetics and Metabolism, 116: 119-124 (2015) http://www.sciencedirect.com/science/article/pii/S1096719215300305 

Wei, C., Q. Lu, S.K. Khoo, M. Lenski, R. Fichorova, and N. Paneth.  Comparison of frozen and unfrozen blood spots for gene expression studies.  Journal of Pediatrics, 164:189-191 (2014) http://www.jpeds.com/article/S0022-3476(13)01148-7/fulltext

Slaughter, J., C. Wei, S. Korzeniewski, Q. Lu, J.S. Beck, S.K. Khoo, A. Brovont, J. Maurer, D. Martin, M. Lenski, and N. Paneth.  High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.  Journal of Maternal-Fetal & Neonatal Medicine, 26:1765-1767 (2013)  http://www.tandfonline.com/doi/full/10.3109/14767058.2013.804050

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatrics Research, 73:450-456 (2013) http://www.nature.com/pr/journal/v73/n4-1/full/pr2012200a.html

Resau, J.H., N.T. Ho, K. Dykema, M.S. Faber, J. V. Busik, R.Z. Nickolov, K.A. Furge, N. Paneth, S. Jewell, and S.K. Khoo.  Evaluation of sex-specific gene expression in archived dried blood spots (DBS).  International Journal of Molecular Sciences, 13:9599-9608 (2012) http://www.mdpi.com/1422-0067/13/8/9599

Khoo, S.K., K. Dykema, N.M. Vadlapatla, D. LaHaie, S. Valle, D. Satterthwaite, S.A. Ramirez, J.A. Carruthers, P.T. Haak, and J.H. Resau. Acquiring genome-wide gene expression profiles in Guthrie card blood spots using microarrays. Pathology International, 61:1-6 (2011)  http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1827.2010.02611.x/full

Fisheries Science

Ozaki, A., S.K. Khoo, Y. Yoshiura, M. Ototake, T. Sakamoto, J.M. Dijkstra, and N. Okamoto. Identification of additional quantitative trait loci (QTL) responsible for susceptibility to infectious pancreatic necrosis virus in rainbow trout. Fish Pathology, 42:131-140 (2007)  https://www.jstage.jst.go.jp/article/jsfp/42/3/42_3_131/_article

Khoo, S.K., A. Ozaki, F. Nakamura, T. Akutsu, S. Ishimoto, R. Nickolov, T. Sakamoto, A. Tetsuya, M. Mochizuki, I. Denda, and N. Okamoto. Identification of a novel chromosomal region associated with infectious hematopoietic necrosis (IHN) resistance in rainbow trout Oncorhynchus mykiss. Fish Pathology, 39:95-101 (2004)  https://www.jstage.jst.go.jp/article/jsfp1966/39/2/39_2_95/_article

Ozaki, A., T. Sakamoto, S.K. Khoo, K. Nakamura, M.R.M. Coimbra, T. Akutsu, and N. Okamoto. Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout ( Oncorhynchus mykiss). Molecular Genetics and Genomics, 265:23-31 (2001) http://link.springer.com/article/10.1007/s004380000392

Sakamoto, T., R.G. Danzmann, K. Gharbi, P. Howard, A. Ozaki, S.K. Khoo, R.A. Woram, N. Okamoto, M.M. Ferguson, L.-E. Holm, R. Guyomard, and B. Hoyheim. A microsatellite linkage map of rainbow trout ( Oncorhynchus mykiss) characterized by large sex-specific differences in recombination rates. Genetics, 155:1331-1345 (2000)  http://www.genetics.org/content/155/3/1331

Khoo, S.K., A. Ozaki, T. Sakamoto, and N. Okamoto. Four highly polymorphic dinucleotide microsatellites in rainbow trout ( Oncorhynchus mykiss). Animal Genetics, 31:73 (2000) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2052.2000.579-8.x/full

Others

Xu, E.H, Y. He, J. Shi, W. Yi, X. Ren, X. Gao, J. Li, N. Wu, K. Weaver, Q. Xie, S.K. Khoo, T. Yang, X. Huang, and K. Melcher.  Discovery of a highly potent glucocorticoid for asthma treatment.  Cell Discovery, 1:15035 (2015)   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822341/

Joshi, N., R-W. Su, C. Gadisetti, S.K. Khoo, J-W. Jeong, S. Young, B. Lessy, and A. Fazleabas. Altered expression of microRNA-451 (miR-451) in eutopic endometrium of baboons (Papio anubis) with endometriosis. Human Reproduction, 30:2881-2891 (2015)  http://humrep.oxfordjournals.org/content/30/12/2881.abstract

Khoo, S.K., D. Petillo, M. Parida, A.C. Tan, J.H. Resau, and S.K. Obaro. Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. BMC Infectious Disease, 11:241(2011)  http://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-11-241