Sok Kean Khoo Ph.D.

Distinguished Associate Professor of Molecular Genomics

Department of Cell and Molecular Biology

554 Cook-DeVos Center for Health Sciences 

Phone: 616-331-5916 

Email: khoos@gvsu.edu

Office Hour 

MAK B4-212: M 11:30am-1pm  W 3-4pm (Fall14 Oct. 15-Dec. 9)

CHS 554: By appointment only

 

Education

Postdoctoral Fellow (Cancer Genetics and Genomics) Van Andel Institute, Grand Rapids, MI

Ph.D. (Fisheries Genetics) Tokyo University of Marine Science and Technology, Tokyo, Japan

M.S. (Reproductive Physiology) University of Science Malaysia, Penang, Malaysia

B.S. (Aquatic Biology, minor in Management) University of Science Malaysia, Penang, Malaysia

 

Courses

BIO 405 (Fall 14) - Cellular & Molecular Biology

CMB 480 (Winter 15) - Responsible  Conduct of Research

 

Research Interests

Molecular biomarker discovery / development, biospecimen science, host response to environmental changes

 

Current Grant Support Research

Circulating microRNAs: a new paradigm for Parkinson's disease biomarker discovery (Michael J. Fox Foundation grant award)

Global genomic and proteomic profiling of African children with typhoid fever (NIH NIAID subaward; PI Obaro of University Nebraska Medical Center)

Effect of matrix metalloproteinase inhibitor on stapled colorectal anastomosis (Spectrum Health Medical Group subaward; PI Luchtefeld of Spectrum Health)

 

Publications (selected from 53)

Wei, C., Q. Lu, S.K. Khoo, M. Lenski, R. Fichorova, and N. Paneth.  Comparison of frozen and unfrozen blood spots for gene expression studies.  Journal of Pediatrics, 164:189-191 (2014)

Khoo, S.K., L.A. Neuman, L. Forsgren, D. Petillo, and P. Brundin.  Could microRNA expression changes be a reliable clinical biomarker for Parkinson’s disease? Neurodegenerative Disease Management, 3:455–465 (2013)

Ho, N.T., K.A. Furge, W-J, Fu, J. Busik, S.K. Khoo, Q. Lu, M. Lenski, J. Wirth, E. Hurwitz, N. Dodge, J.H. Resau, and N. Paneth.  Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls.  Pediatrics Research, 73:450-456 (2013)

Khoo, S.K., D. Petillo, U.J. Kang, J.H. Resau, B. Berryhill, J. Linder, L. Forsgren, L.A. Neuman, and A.C. Tan.  Plasma-based circulating microRNA biomarkers for Parkinson’s disease.  Journal of Parkinson’s Disease, 2:321-331(2012)

Khoo, S.K., K. Dykema, N.M. Vadlapatla, D. LaHaie, S. Valle, D. Satterthwaite, S.A. Ramirez, J.A. Carruthers, P.T. Haak, and J.H. Resau.  Acquiring genome-wide gene expression profiles in Guthrie card blood spots using microarrays.  Pathology International, 61:1-6 (2011)

Khoo, S.K., D. Petillo, M. Parida, A.C. Tan, J.H. Resau, and S.K. Obaro. Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children.  BMC Infectious Disease, 11:241(2011)

Dalgliesh, G.L., K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, J. Teague, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, S. Forbes, M. Jia, D. Jones, H. Knott, C.Y. Kok, K.W. Lau, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, S. O’Meara, E. Pleasance, A. Rajasingham, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, K. Turrell, K.J. Dykema, S.K. Khoo, D. Petillo, B. Wondergem, J. Adema, R.J. Kahnoski, B.T. Teh, M.R. Stratton, and P.A. Futreal.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.   Nature, 463:360-363 (2010)

Khoo, S.K., P. Pendek, R. Nickolov, D.C. Luccio-Camelo, T.L. Newton, A. Massie, D. Petillo, J. Menon, D. Cameron, B.T. Teh, and S-P. Chan.  Genome-wide scan identified novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma.  Endocrine-Related Cancer, 16: 1957-1063 (2009)

van Haaften, G., G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S.   O’Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J.           Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M-L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R.      Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y-T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal.  Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.  Nature Genetics, 41:521-523 (2009)

Matsuda, D., S.K. Khoo, A. Massie, M. Iwamura, J. Chen, D. Petillo, B. Wondergem, M. Avallone, S.J. Kloostra, M-H. Tan, J. Koeman, Z. Zhang, R.J. Kahnoski, The French Kidney Cancer Study Group, S. Baba, and B.T. Teh.  Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters, 272: 260-267 (2008)

Greenman, C., P. Stephens, R. Smith, G. Dalgliesh, C. Hunter, G. Bignell, H. Davies, J. Teague, A. Butler, C. Stevens, S. Edkins, S. O’Meara, T. Avis, S. Barthorpe, G. Bhamra, G. Buck, B. Choudhury, J. Clements, J. Cole, E. Dicks, S. Forbes, K. Gray, K. Halliday, R. Harrison, K. Hills, J. Hinton, A. Jenkinson, D. Jones, A. Menzies, T. Mironenko, J. Perry, K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts, J. Varian, T. Webb, S. West, S. Widaa, A. Yates, D.P. Cahill, D.N. Louis, P. Goldstraw, A.G. Nicholson, F. Brasseur, L. Looijenga, B.L. Weber, Y-E. Chiew, A. deFazio, M.F. Greaves, A.R. Green, D.F. Easton, G. Chenevix-Trench, S.K. Khoo, M-H. Tan, B.T. Teh, S.T. Yuen, S.Y. Leung, R. Wooster, P.A. Futreal, and M. Stratton.  Patterns of somatic mutation in human cancer genomes.  Nature, 446:153-158 (2007)

Sweet, K, J. Willis, X.-P. Zhou, C. Gallione, T. Sawada, P. Alhopuro, S.K. Khoo, A. Patocs, C. Martin, S. Bridgeman, J. Heinz, R. Pilarski, R. Lehtonen, T. Prior, T. Frebourg, B.T. Teh, D.A. Marchuk, L.A. Aaltonen, and C. Eng.  Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.  Journal of American Medical Association, 294:2465-2473 (2005)

Khoo, S.K., A. Ozaki, F. Nakamura, T. Akutsu, S. Ishimoto, R. Nickolov, T. Sakamoto, A. Tetsuya, M. Mochizuki, I. Denda, and N. Okamoto.  Identification of a novel chromosomal region associated with infectious hematopoietic necrosis (IHN) resistance in rainbow trout Oncorhynchus mykiss.  Fish Pathology, 39:95–101 (2004)

Chen, J., W-O. Lui, M.D. Vos, G.J. Clark, M. Takahashi, J. Schoumans, S.K. Khoo, D. Petillo, T. Lavery, J. Sugimura, D. Astuti, C. Zhang, S. Kagawa, E. Maher, C. Larsson, A.S. Alberts, H. Kanayama, and B.T. Teh.  The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.  Cancer Cell, 4:405–413 (2003)

Khoo, S.K., K. Kahnoski, J. Sugimura, D. Petillo, J. Chen, K. Shockley, J. Ludlow, R. Knapp, S. Giraud, S. Richard, M. Nordenskjöld, and B.T. Teh.   Inactivation of BHD in sporadic renal tumors.  Cancer Research, 63:4583–4587 (2003)

Khoo, S.K., S. Giraud, K. Kahnoski, J. Chen, O. Motorna, R. Nickolov, O. Binet, D. Lambert, J. Friedel, R. Levy, S. Frelicot, P. Wolkenstein, P. Hammel, U. Bergerheim, M.-A, Hedblad, M. Bradley, B.T. Teh, M. Nordenskjöld, and S. Richard.  Clinical and genetic studies of Birt-Hogg-Dubé syndrome.  Journal of Medical Genetics, 39:906–912 (2002)

Khoo, S.K., M. Bradley, F.K. Wong, M.-A. Hedblad, M. Nordenskjöld, and B.T. Teh.  Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12–q11.2.  Oncogene, 20:5239–5242 (2001)

Ozaki, A., T. Sakamoto, S.K. Khoo, K. Nakamura, M.R.M. Coimbra, T. Akutsu, and N. Okamoto.   Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout (Oncorhynchus mykiss). Molecular Genetics and Genomics, 265:23–31 (2001)

Sakamoto, T., R.G. Danzmann, K. Gharbi, P. Howard, A. Ozaki, S.K. Khoo, R.A. Woram, N. Okamoto, M.M. Ferguson, L.-E. Holm, R. Guyomard, and B. Hoyheim.  A microsatellite linkage map of rainbow trout (Oncorhynchus mykiss) characterized by large sex-specific differences in recombination rates.  Genetics, 155:1331–1345 (2000)

Khoo, S.K., A. Ozaki, T. Sakamoto, and N. Okamoto.  Four highly polymorphic dinucleotide microsatellites in rainbow trout (Oncorhynchus mykiss). Animal Genetics, 31:73 (2000)

 

Current Laboratory Members

Stephen Orey (Research Technician)

Ghada Mohsen (Special Project GA / MS Independent Study)

Derrick Kroodsma (PSM Intern)

Sayantoni Mukhopadhyay (PSM Intern)

John Skutnik (MS Independent Research)

William Thompson (BS Independent Research)

Page last modified September 18, 2014