Osman Patel, Ph.D.

Associate Professor of CMB
Phone: 616-331-2470
Email: patelo@gvsu.edu

 

Education

Ph D (Vet. Med.) University of Tokyo

Master’s (Vet. Med.) University of Glasgow

Bachelor’s (Vet. Med.) University of Zambia

 

Research Experience-Postdoctoral Fellow

2000-2002 Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences, Tsukuba, Japan

2003-2008 Department of Animal Sciences, Michigan State University, East Lansing, USA

 

Courses taught:

CMB 610 (Foundations of Biotechnology)

CMB 620 (Techniques in Cell and Tissue Culture)

CMB 680 (Scientific Communication)

BIO 325 (Human Sexuality)

BIO 406 (Cell and Molecular Biology Laboratory)

HNR 311 (Biotechnology and The World)

 

Research interests:

My broad research interests lie in understanding:

  1. Endocrine, metabolic and molecular interactions coordinating physiological (homeostatic/homeorhetic) adaptation in key metabolic tissues during pregnancy and lactation, and delineating the aberrations induced by exposure to altered gravity.

  2. The biochemical and molecular constituents of an oocyte/embryo endowed with capacity to develop. Specifically, identify constituents that can aid in predicting developmental capacity and serve as reliable selection markers for assisted reproductive technologies.

  3. Molecular and cellular developmental chronology of a placenta, in particular, the cross-talk at the fetal, maternal and placental interface.

 

Peer-reviewed Publications:

  1. Patel O., Casey T., Dover H., Plaut K. Homeorhetic adaptation to lactation: comparative transcriptome analysis of mammary, liver, and adipose tissue during the transition from pregnancy to lactation in rats. Functional & Integrative Genomics 2011, 11: 193 (Epub 2010 Sep 18)

  2. Casey T, Patel O, Dykema K, Dover H, Furge K, Plaut K. Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation. PLos ONE 2009, 4(10): e7395.

  3. Nakaya Y, Kizaki K, Takahashi T, Patel OV, Hashizume K. Characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 genes. BMC Molecular Biology 2009, 10:19.

  4. Casey T, Bond J, Tighe S, Hunter T, Lintault L, Patel O, Eneman J, Crocker A, White J, Tessitore J, Stanley M, Harlow S, Weaver D, Muss H, Plaut K. Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer. Breast Cancer Res. Treat. 2009, 114:47-62.

  5. Patel OV, Zakrzewska E, Maple RL, Baer L, Ronca A, Wade C, Plaut K. Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion. Eur. J. Appl. Physiol. 2008, 104: 847-58.

  6. Bettegowda A, Patel OV, Lee K, Park K, Ireland JJ, Smith GW. Identification of novel cumulus cell molecular markers predictive of oocyte competence: Functional and diagnostic implications. Biol Reprod. 2008, 79: 301-9.

  7. Hashizume K, Ushizawa K, Patel OV, Kizaki K, Imai K, Yamada O, Nakano H, Takahashi T. Gene expression and maintenance of pregnancy in bovine: roles of trophoblastic binucleate cells-specific molecules. Reprod Fert Dev 2007, 19: 79-90.

  8. Patel OV, Maple R, Bear L, Ronca A., Wade C. and Plaut K. Tissue-specific variation in expression of prolactin receptor gene subtypes in hypergravity-exposed rats. J. Gravit. Physiol. 2007, 14: 129-130.

  9. Bettegowda A, Yao J, Sen A, Li Q, Lee K, Kobayashi Y, Patel OV, Coussens PM, Ireland JJ, Smith GW. JY-1, a novel oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle. Proc. Natl. Acad. Sci. USA 2007, 104: 17602-7.

  10. Patel OV, Bettegowda A, Ireland JJ, Coussens PM, Lonergan P, Smith GW. Functional genomics studies of oocyte competence: Evidence that reduced transcript for follistatin is associated with poor developmental competence of bovine oocyte. Reprod 2007, 133: 95-106.

  11. Samma P, Patel OV, Bettegowda A, Ireland JJ, Smith GW. A novel algorithm for transcriptome analysis. Physiol genomics 2006, 28: 62-66.

  12. Corcoran D, Fair T, Park S, Rizos D, Patel OV, Smith GW, Coussens PM, Ireland JJ, Boland MP, Evans ACO, Lonergan P. Suppressed Expression of Genes Involved In Transcription And Translation In In Vitro Compared To In Vivo Cultured Bovine Embryos. Reproduction 2006, 131: 651-660.

  13. Bettegowda A, Patel OV, Ireland JJ, Smith GW. Quantitative Analysis of Messenger RNA Abundance for Ribosomal Protein L-15, Cyclophilin-A, Phosphoglycerokinase, β-glucuronidase, Glyceraldehyde 3-Phosphate Dehydrogenase, β-Actin and Histone H2A during Bovine Oocyte Maturation and Early Embryogenesis In Vitro. Mol Reprod Dev. 2006, 73:267-78.

  14. Patel OV, SuchytaS, Sipkovsky SS, Yao J, Ireland JJ, Coussens PM, Smith GW. Validation and application of a high fidelity mRNA linear amplification procedure for profiling gene expression. Veterinary Immunology and Immunopathology 2005, 105: 331-42.

  15. Patel OV , Takahashi T, Imai K, Hashizume K. Characterization of native and recombinant bovine pregnancy-associated glycoproteins. Res Vet Sci 2004, 77: 203-210.

  16. Patel OV, Yamada O, Kizaki K, Takahashi T, Imai K, Takahashi S, Izaike Y, Schuler LA, Takezawa T, Hashizume K. Expression of trophoblast cell-specific pregnancy-related genes in somatic cell-cloned bovine pregnancies. Biol Reprod. 2004, 70: 1114-20.

  17. Patel OV, Yamada O, Kizaki K, Takahashi T, Imai K, Hashizume K. Quantitative analysis throughout pregnancy of placentomal and interplacentomal expression of pregnancy-associated glycoproteins-1 and -9 in the cow. Mol Reprod Dev. 2004, 67: 257-63.

  18. Ishiwata H, Katsuma S, Kizaki K, Patel OV, Nakano H, Takahashi T, Imai K, Hirasawa A, Shiojima S, Ikawa H, Suzuki Y, Tsujimoto G, Izaike Y, Todoroki J, Hashizume K. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Molecular Reproduction and Development. Mol Reprod Dev. 2003, 65: 9-18.

  19. Takahashi T, Hirako M, Patel OV, Shimizu M, Hasegawa Y, Domeki I, Hashizume K. Plasma steroid profiles following follicle-stimulating hormone or equine chorionic gonadotropin injection in cows chronically treated with gonadotropin-releasing hormone agonist. J Vet Med Sci. 2002, 64: 731-4.

  20. Hashizume K, Ishiwata H,Kizaki K, Yamada O, Imai K, Takahashi T, Patel OV, Akagi S, Shimizu M, Takahashi S, Tsujimoto G, Todoroki J and Izaike Y. Implantation and placental development in somatic cell clone recipient cows. Cloning and Stem Cells 2002, 4: 197-209.

  21. Yamada O, Kizaki K, Takahashi T, Imai K, Patel OV, Schuler LA and Hashizume K. Prolactin-related protein-1 at the feto-maternal interface during the implantation period in cows. Reproduction. 2002, 124: 427-37.

 

Presentations by mentored graduate student:

  1. K. Gebre-Egziabher, J. Resau, K. Plaut, O. Patel . Exposure to hypergravity during pregnancy and early lactation alters abundance of cytoskeletal and extracellular matrix proteins in a rat model. Annual Biomedical Research Conference for Minority Students (November, 2011).

  2.  K. Gebre-Egziabher, J. Resau, O. Patel. Effect of increased g-load on rat mammary gland development. 7th Annual MichBio Expo & Conference (November, 2011).

 

Presentations by mentored undergraduate student:

  1. Reiber C, Fisch AJ,  Smart R, Schroeder W, Patel, OV. Effects of chronic low-dose anti-telomerase and chemotherapeutic drugs on breast cancer cells. Mid-Michigan Symposium for Undergraduate Research Experiences at MSU (July 23rd, 2014)

  2. Fisch, AJ, Smart, R., Schroeder, W., Patel, O. BIBR 1532 inhibits the growth of breast cancer cells. Mid-East Honors Association, GVSU Frederick Meijer Honors College (April 4-6, 2014).

  3. Fisch AJ, Uzarski R, Smart R, Schroeder W, Patel, OV. Effect of telomerase inhibitors on breast cancer cells. West Michigan Undergraduate Research Conference at Van Andel Institute (November 16th, 2013) 

  4. E. Iordanou, Patel OV. Alternate source of serum for mammalian cell culture. West Michigan Regional Undergraduate Research Conference at the Van Andel Institute (October 2009).

  5. VanKlompenberg MK, Patel OV and Plaut K. Transcript abundance of lipogenic enzymes parallels lipid metabolism in the mammary gland of rats exposed to altered gravity during pregnancy. 23rd Annual Meeting American Society for Gravitational and Space Biology, October 2007, Ames Research Center, Moffett Field, CA. (3rd Place Undergraduate Research Animal Poster)

  6. VanKlompenberg MK, Patel OV and Plaut K. Hypergravity exposure affects lipid synthesis in rat mammary gland during pregnancy and lactation. American Dairy Science Association and American Society of Animal Science Joint Midwest Meeting, March 19-21, 2007, Des Moines, IA. (3rd Place Undergraduate Oral Paper Presentation)

  7. VanKlompenberg MK, Patel OV, Dover H and Plaut K. Effect of hypergravity on expression of receptors associated with lactogenesis in rat mammary gland from pregnancy to lactation. 22nd Annual Meeting American Society for Gravitational and Space Biology, November 2-5, 2006, Arlington, VA. (1st Place Undergraduate Research Animal Poster)

Page last modified August 25, 2014