All Spotlights » Rachel Powers receives NIH AREA (R15) Award
Rachel Powers (Associate Professor of Chemistry) was recently awarded an AREA (R15) grant from the National Institutes of Health ($388,758). The title of the project is "Structure-based discovery and design of novel class D beta-lacatamase inhibitors." Currently, antibiotic resistance is one of the most pressing public health crises of the 21st century, and beta-lactamases are the most widespread resistance mechanism to beta-lactam antibiotics, like penicillin and cephalosporins. In particular, the class D beta-lactamases are clinically relevant targets for which there are no known inhibitors. The proposed research focuses on the optimization of two classes of compounds with the potential to become the first clinical inhibitors for class D beta-lactamases. This grant supports the project for three years and will provide funding for two undergraduate students to conduct research in her lab during each of the three summers.