Brad Wallar - Publications

Full Curriculum Vitae (in pdf format)

PUBLICATIONS (Peer-Reviewed) - my undergraduate students are underlined and contain a *

Wallar, B. J., DeWard, A. D., Resau, J. H., Alberts, A. S. (2007) RhoB and the Mammalian Diaphanous-related Formin mDia2 in Endosome Trafficking Exp Cell Res 313(3):560-571.

Wallar, B. J., Stropich*, B. N., Schoenherr*, J. A., Holman, H.A., Kitchen, S.M., Alberts, A. S. (2006) The basic region of DAD is required for autoregulatory interactions with the Diaphanous-related Formin inhibitory domain. J. Biol. Chem. 281:4300-4307.

Zhang, J., Wallar, B. J., Popescu, C. V., Renner, D. B., Thomas, D. D., Lipscomb, J. D. (2006) Methane Monooxygenase Hydroxylase and B Component Interactions. Biochemistry 45:2913-26.

Colucci-Guyon, E., Niedergang, F., Wallar, B. J., Peng, J., Alberts, A. S., Chavrier, P. (2005) A role for mammalian Diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages. Current Biology 15:2007-2012.

Wen, Y., Eng, C. H., Schmoranzer, J., Cabrera-Poch, N, Morris, E. J. S., Chen, M., Wallar, B.J., Alberts, A. S., Gundersen, G. G. (2004) EB1 and APC interact with mDia to selectively stabilize microtubules downstream of Rho and promote cell migration. Nature Cell Biology 6:820-830.

Brazeau, B. J., Wallar, B. J., Lipscomb, J. D. (2003) Effector proteins from P450cam and methane monooxygenase: lessons in tuning nature's powerful reagents. Biochem. Biophys. Res. Comm. 312:143-148.

Wallar, B. J., Alberts, A. S. (2003) The formins: active scaffolds that remodel the cytoskeleton. Trends Cell Biol. 13(8):435-446.

Wallar, B. J., Peng, J., Flanders, A., Swiatek, P. J., Alberts, A. S. (2003) Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 (mDia2) as an effector for Cdc42. Current Biology 13:534-545.

Brazeau, B. J., Wallar, B. J., Lipscomb, J. D. (2001) Unmasking of deuterium kinetic isotope effects on the methane monooxygenase compound Q reaction by site-directed mutagenesis of component B. J. Am. Chem. Soc. 123(42): 10421-10422.

Chang, S. L., Wallar, B. J., Lipscomb, J. D., Mayo, K. H. (2001) Residues in Methylosinus trichosporium OB3b methane monooxygenase component B involved in molecular interactions with reduced- and oxidized-hydroxylase component: a role for the N-terminus. Biochemistry. 40(32): 9539-9551.

Wallar, B. J., Lipscomb, J. D. (2001) Methane monooxygenase component B mutants alter the kinetics of steps throughout the catalytic cycle. Biochemistry 40(7): 2220-2233.

Chang, S. L., Wallar, B. J., Lipscomb, J. D., Mayo, K. H. (1999) Solution structure of component B from methane monooxygenase derived through heteronuclear NMR and molecular modeling. Biochemistry 38(18):5799-5812.

Elango, N., Radhakrishnan, R., Froland, W. A., Wallar, B. J., Earhart, C. A., Lipscomb, J. D., Ohlendorf, D. H. (1997) Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium Ob3b. Protein Science 6:556-568.

Wallar, B. J., Lipscomb, J. D. (1996) Dioxygen activation by enzymes containing binuclear non-heme iron clusters. Chemical Reviews 96:2625-2657.

PUBLICATIONS (Book Chapters or Research Proceedings)

Eisenmann, K.M., Peng, J., Wallar, B.J., and Alberts, A.S. (2005) Rho GTPase-Formin Pairs in Cytoskeletal Remodeling, in Signaling Networks in Shape and Motility. London, U.K.: Novartis Foundation, Novartis Found Symp. 269:206-230.

Lipscomb, John D., Brazeau, Brian J., Wallar, Bradley J. (2002) Methane monooxygenase and compound Q: lessons in oxygen activation. International Congress Series 1233 (Oxygen and Life):205-212.

Lipscomb, John D., Brazeau, Brian J., Wallar, Bradley J. (2001) Kinetics and regulation of MMO compound Q reaction with substrates. Abstracts of Papers - American Chemical Society 221st: INOR-048.

Lipscomb, John D., Lee, Sang-Kyu, Nesheim, Jeremy C., Jin, Yi, Wallar, Bradley J., Zhang, Xiao-Yun. (1999) Intermediates in the reaction cycle of methane monooxygenase: structure and chemistry. Editor(s): Ferreira, Gloria C.; Moura, Jose J. G.; Franco, Ricardo. Iron Metabolism pp 323-339. Wiley-VCH Verlag GmbH, Weinheim, Germany.

POSTER PRESENTATIONS AT INTERNATIONAL MEETINGS - my undergraduate students are underlined and contain an *

Schillaci-Schofield*, M.M., Hehl*, B., Wallar, B.J. (2009)Identification of specific protein regions involved in the cellular regulation of the Diaphanous-related Formin, DAAM1. American Society for Cell Biology Annual Meeting, San Diego, CA. 2513/L109.

Seaberg*, S., Wallar, B.J. (2009) Subcloning, expression, and cellular regulation of the Diaphanous-related Formin, mDia3. American Society for Cell Biology Annual Meeting, San Diego, CA. 2514/L110.

June, C.M., Rawson*, J.M., Benson*, B.E., Albaugh*, B.N., Veltman*, K.J., Alberts, A.S., Wallar, B.J. (2009) The role of phosphorylation in the regulatory mechanism of the Diaphanous-related formins. American Society for Biochemistry and Molecular Biology Annual Meeting, New Orleans, LA. FASEB Journal 23:704.5.

Rawson*, J.M., Veltman*, K.J., Wallar, B.J. (2008) The role of phosphorylation in the regulatory mechanism of the Diaphanous-related formins. American Society for Biochemistry and Molecular Biology Annual Meeting, San Diego, CA. FASEB Journal 22:2079.

Hehl*, B., Wallar, B.J. (2007) Identification of specific protein regions involved in the regulation of the Diaphanous-related Formin, DAAM1.< American Society for Biochemistry and Molecular Biology Annual Meeting, Washington, DC. FASEB Journal 21:787.8

Rawson*, J.M., Stropich*, B.N., Alberts, A.S., Wallar, B.J. (2007) Probing the specific amino acid residues involved in the regulation of the Diaphanous-related Formins. American Society for Biochemistry and Molecular Biology Annual Meeting, Washington, DC.FASEB Journal 21:787.9

DeWard A.D., Wallar, B.J., Alberts, A.S. (2006) RhoB and the Mammalian Diaphanous-related Formin mDia2 Govern Actin Dynamics on Endosomes Necessary for Trafficking and Vesicle Fusion. American Society for Cell Biology. San Diego, CA. FASEB Journal 1652/B234

Stropich*, B.N.,Schoenherr*, J.A., Holman, H., Alberts, A.S., Wallar, B.J. (2006) Probing the protein interactions involved in the regulation of the Diaphanous-related Formins. American Society for Biochemistry and Molecular Biology Annual Meeting, San Francisco, CA. FASEB Journal 20(4):608.5

Wallar, B.J., Peng, J., Collins, K.A., Eisenmann, K.E., Alberts, A.S. (2005) RhoB and the Mammalian Diaphanous-related Formin mDia2 Govern Actin Dynamics on Endosomes Necessary for Trafficking and Vesicle Fusion. American Society for Cell Biology. San Francisco, CA. FASEB Journal 1705/B194

Schoenherr*, J.A., Holman, H., Alberts, A.S., Wallar, B.J. (2005) Probing the protein interactions involved in the regulation of the Diaphanous-related Formins. American Society for Biochemistry and Molecular Biology Annual Meeting, San Diego, CA. FASEB Journal 19(4):503.4

Wallar, B.J., Eisenmann, K.E., Alberts, A.S. (2004) Rho GTPases, Src, and Diaphanous-related Formin complexes in trafficking of EGF receptors. American Society for Biochemistry and Molecular Biology Annual Meeting, Boston, MA. FASEB Journal 18(8):70.10

Wallar, B.J., Peng, J., Vankirk, A., Condeelis, J., Chardin, P., Alberts, A. (2002) Dual actin remodeling activities for the Diaphanous-related Formins in Rho signaling: mDia2 regulates Arp2/3 and eEF1A. FASEB Summer Research Conference: Small G-Proteins and Cell Dynamics. C3. Snowmass, CO.

Wallar, B.J., Gournier, H., Gordon, A., Peng, J., Vankirk, A., Gundersen, G., Welch, M., Alberts, A. (2002) Dynamic regulation of of the Diaphanous-related Formins during Rho GTPase regulated cytoskeletal remodeling. Keystone Meeting: Protein Phosphorylation and Mechanism of Cellular Regulation. X2-120. Taos, NM.

Wallar, B.J., Lipscomb, J.D. (1999) Probing the interactions between component B and the hydroxylase of methane monooxygenase. J. Inorg. Biochem. 74:332, Minneapolis, MN.

Wallar, B.J., Lipscomb, J.D. (1998) Using steady state and transient kinetics to probe the interactions between component B and the hydroxylase of methane monooxygenase. The 26th Steenbock Symposium: Enzymatic Mechanisms. P42, Madison, WI.

Wallar, B.J., Lipscomb, J.D. (1997) Probing the interactions between component B and the hydroxylase of methane monooxygenase. American Society for Biochemistry and Molecular Biology Annual Meeting, FASEB Journal 11:A1304, San Francisco, CA.

Lipscomb, J.D., Nesheim, J.C., Lee, S.-K., Wallar, B.J., Zhang, X.Y. (1997) Structure and reactivity of intermediates in the oxygen activation mechanism of methane monooxygenase. J. Inorg. Biochem. 67:314, Yokohama, Japan.

Liu, Y., Nesheim, J.C., Paulsen, K.E., Wallar, B.J., Stankovich, M.T., Lipscomb, J.D. (1995) Roles of component B and reductase in methane monooxygenase (MMO) turnover. J. Inorg. Biochem. 59:368, Lübeck, Germany.

ORAL AND POSTER PRESENTATIONS BY STUDENTS AT REGIONAL/LOCAL MEETINGS - my undergraduate students are underlined and contain a *

Schillaci-Schofield*, M.M., Hehl*, B., Wallar, B.J. (2009) Identification of specific protein regions involved in the cellular regulation of the Diaphanous-related Formin, DAAM1. West Michigan Regional Undergraduate Science Research Conference. Van Andel Institute, Grand Rapids, MI.

Seaberg*, S., Wallar, B.J. (2009) Subcloning, expression, and cellular regulation of the Diaphanous-related Formin, mDia3. West Michigan Regional Undergraduate Science Research Conference. Van Andel Institute, Grand Rapids, MI.

Benson*, B, Alberts, A.S., Wallar, B.J. (2008) Studying potential drug interactions involved in the regulation of the Diaphanous-related formins. GVSU Student Summer Scholars Summer Showcase.

Hehl*, B., Wallar, B.J. (2008) Investigating the Formin Protein Family: A Focus on DAAM1. GVSU Student Scholarship Day.

Veltman*, K. J., Wallar, B.J. (2008) Molecular Regulation of the Diaphanous-related Formins. GVSU Student Scholarship Day.

Rawson*, J., Veltman*, K. J., Stropich*, B.N., Alberts, A.S., Wallar, B.J. (2007) Probing the specific amino acid residues involved in the regulation of the Diaphanous-related formins. West Michigan Regional Undergraduate Science Research Conference. Van Andel Institute, Grand Rapids, MI.

Hehl*, B., Wallar, B.J. (2007) Identification of specific protein regions involved in the regulation of the Diaphanous-related Formin, DAAM1. West Michigan Regional Undergraduate Science Research Conference. Van Andel Institute, Grand Rapids, MI.

Veltman*, K. J., Rawson*, J., Stropich*, B.N., Alberts, A.S., Wallar, B.J. (2007) Probing the specific amino acid residues involved in the regulation of the Diaphanous-related formins. GVSU Student Summer Scholars Summer Showcase.

Hehl*, B., Wallar, B.J. (2007) Identification of specific protein regions involved in the regulation of the Diaphanous-related Formin, DAAM1. GVSU Student Scholarship Day.

Rawson*, J., Wallar, B.J. (2007) Probing the important protein interactions involved in the regulation of cell movement. GVSU Student Scholarship Day.

Hehl*, B., Stropich*, B.N., Rawson*, J., Alberts, A.S., Wallar, B.J. (2006) Analysis of specific amino acid residues potentially involved in the regulation of the Diaphanous-related Formins. 17th Annual Argonne Symposium for Undergraduates in Science, Mathematics, and Engineering. Cell Biology Symposium. Argonne, IL.

Rawson*, J., Stropich*, B.N., Alberts, A.S., Wallar, B.J. (2006) Probing the specific residues involved in the regulation of the Diaphanous-related Formins. 17th Annual Argonne Symposium for Undergraduates in Science, Mathematics, and Engineering. Biochemistry Symposium. Argonne, IL.

Rawson, J., Wallar, B.J. (2006) Probing important protein interactions in the mammalian Diaphanous-related Formins: How a single amino acid residue can affect the entire skeletal network of the cell. GVSU Student Summer Scholars Summer Showcase.

Hehl*, B., Wallar, B.J. (2006) Exploring important protein interactions involved in the regulation of the Diaphanous-related Formins. Penn State University McNair Scholars Conference.

Stropich*, B.N, Wallar, B.J. (2006) Probing the important protein interactions involved in the regulation of cell movement. GVSU Student Scholarship Day.

Stropich*, B.N, Wallar, B.J. (2005) Probing the important protein interactions involved in the regulation of cell movement. GVSU Student Summer Scholars Summer Showcase.

Schoenherr*, J.A., Wallar, B.J. (2005) Probing the specific residues involved in the regulation of the Diaphanous-related Formins. GVSU Student Scholarship Day.

Schoenherr*, J.A., Wallar, B.J. (2004) Probing the specific residues involved in the regulation of the Diaphanous-related Formins. GVSU Student Summer Scholars Summer Showcase.

Page last modified May 12, 2011